http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101717449-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a67f7c5d1c3c050f5beb9ca32a6dc4b2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2adb38898324cd8356b93ff2909f1bce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_493899e46dad1cd2188c3271c9c196de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12448b0b8e4c308d71285152ae6db0b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86623f8d9499119ebd5285cffb3de894 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50b9fa65633692d0d31c842ba390481f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e6029b3d38b5343587ea08c0e080e3b |
| publicationDate | 2013-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101717449-B |
| titleOfInvention | Recombinant TRAIL-Fc fusion protein as well as preparation and application thereof |
| abstract | The invention relates to a design technology for fusion protein and a protein expression and purification technology, and relates the application of fusion protein as a tumor therapeutic medicament. The invention is characterized by fusing the 114th-281th amino acid of tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) with human IgGlFc. The fused protein consists of 400 amino acids, the isoelectric point pI is 9.34, and theoretical molecular weight is 45535.30. The protein exists by a dimer or a trimer, can remarkably induce apoptosis of a plurality of kinds of tumor cellsand kills or/and inhibit tumor cells in an animal body. Compared with TRAIL, the TRAIL-Fc fusion protein has large molecular weight, high activity and long vivo half-life, is expressed by mammalian cells, and can be used as a tumor therapeutic medicament. |
| priorityDate | 2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.