http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101704892-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_279b4c171d4ef5996ccd96c093a55ddf |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2009-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3582d04158ea52d1f536e834ce1c8ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae07823f80680f2d930f5702146faed9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aec53ebe222c39647f55b073f226a51e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa306541f9a9117b7c0a3b5dc79931a1 |
| publicationDate | 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101704892-B |
| titleOfInvention | Anti-uPAR humanized antibody, coding gene and application thereof |
| abstract | The invention discloses an anti-uPAR humanized antibody, a coding gene and application thereof. The amino acid sequence of a heavy chain variable region of the antibody is shown as a sequence 3 in a sequence table, and the amino acid sequence of a light chain of the antibody is shown as a sequence 1 in the sequence table. Experiment results confirm that the antibody has good binding activity (affinity is 1.74*10-8 mol/L) and capability of inhibiting the growth and migration of tumor cells. The humanized antibody can be bound better to uPAR so as to guarantee anti-tumor effect thereof. A method for preparing the antibody can simultaneously express the light chain and a heavy chain and ensure that the expression ratio of the light chain to the heavy chain is closer to 1:1 so as to produce the antibody with double chains mutually matched in a higher ratio. In summary, the antibody and the preparation method thereof can have broad application prospects in the field of preventing and/or treating tumors. |
| priorityDate | 2009-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 405.