http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101704872-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c9acb62b177ef5942ca91f244e41f48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9775b294ed6a04a3d7d44fd25773d48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e663b4d67f16f7a14aea68a45ad4e9a7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 |
| filingDate | 2009-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f3cfbb5d06dc65dd140c9724120e47b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a3a507a248d75d715c592ee2f03262f |
| publicationDate | 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101704872-B |
| titleOfInvention | 23-hydroxybetulinic acid derivatives as well as preparation methods and application thereof |
| abstract | The invention discloses three new 23-hydroxybetulinic acid derivatives, i.e. 3-carboxy-23-hydroxybetulinic acid, 3-carboxy-23-dihydrobetulinic acid and 23-dihydrobetulinic acid, and also discloses preparation methods of the three new compounds. The three new compounds can widely restrain the growth of various types of human tumor cell lines and further induce apoptosis of tumor cells. In the research of human tumor xenograft models, the 3-carboxy-23-hydroxybetulinic acid is proved to be an effective antineoplastic agent which can intensively restrain cells of human melanoma, leukemia, malignant gliomas, prostatic cancer, lung cancer and colon cancer from growing in a human body, thereby having great potential to be developed into a new broad-spectrum antitumor drug. Furthermore, the three new compounds also have a function for resisting HIV virus, particularly, the function of the 3-carboxy-23-dihydrobetulinic acid for resisting the HIV virus is strongest and even stronger than that of a positive control group of an anti-AIDS drug used in clinic, therefore, the 3-carboxy-23-dihydrobetulinic acid has great potential to be developed into a new anti-AIDS drug. |
| priorityDate | 2009-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.