http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101680018-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0691 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2008-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101680018-B |
| titleOfInvention | Application of the endothelium/smooth muscle cell co-culture model of extracorporeal hemodynamic in the new therapeutic targets of identification vascular diseases |
| abstract | The present invention relates to putting on the external biological mechanical model of the humans/animals cell in culture for Hemodynamics (i.e. blood flow) pattern after human circulation is modeled.This model has reappeared measured directly from human circulation using non-invasive magnetic resonance imaging and has translated to the Hemodynamics stream mode for controlling the motor that vertebra platform is rotated.Vertebra platform immerses in fluid (i.e. cell culture medium) and reaches close to the cell surface grown in planar surface.The rotation of vertebra platform senses momentum on fluid and produces the shear stress according to time change in flat board or cell surface.This model most closely simulates the physiological blood kinetic force for putting on endothelial cell (cells of lining blood vessels) in vivo and the limitation for overcoming the stream device for applying more simplified non-physiologic flow formula in the early time.Another aspect of the present invention is related to the co-cultivation ware with reference to Transwell.This permission two kinds of physical separation, three or more different cell type under culture dish environment, while internal cell surface to be exposed to the Hemodynamics stream mode of simulation.Other important changes include that customized flows in and out pipeline individually and independently to supply culture medium, medicine etc. to both inner and outer rooms of co-culture model.Physiological temp and gas concentration is controlled using external module.Allow respectively to separate each cellular layer or surface for bioanalysis array (i.e. protein, gene etc.) by the physical separation of artificial T ranswell films and the attached cell of the bottom of Petri wares. |
| priorityDate | 2007-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 267.