http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101679474-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7bbf0cb262a0b75b400e780e8a078265 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 2007-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_810d86a18e1f8b1c490c8ce3a1844892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2512e8a8f64a3328866b4270f6357044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b834f7b062ddece92abb82d13cde917a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e47208bdbedad38d6292a51b931f48b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8a76bb17b0cbf879f3ddd08c826c5ff |
| publicationDate | 2010-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101679474-A |
| titleOfInvention | synthesis of oligonucleotides |
| abstract | A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having the formula (1), wherein B is a heterocyclic base and the radicals R2, R3 and R5 are as defined in the description; b) reacting said compound with a phosphitylating agent in the presence of an activator having the formula (I) (activator I)), wherein R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; R1, R2 = either H or form a 5 to 6-membered ring together; X1, X2 = independently either N or CH; Y = H or Si(R4)3, with R4= alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; B = deprotonated acid; to prepare a phosphitylated compound; c) reacting said phosphitylated compound without isolation with a second compound having the formula (1), wherein R5, R3, R2,B are independently selected, but have the same definition as above in the presence of an activator II selected from the group of imidazole imidazolium salts and mixtures thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103476784-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103476784-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9029528-B2 |
| priorityDate | 2007-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.