| abstract |
The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula (VIII) in which at least one of the groups X<1>, X<2>, X<3> is selected from fluoro, chloro, bromo, hydroxy, methoxy, ethoxy, trifluoromethyl, amino whereas the other groups X<1>, X<2>, X<3> have the meaning of a hydrogen atom, in which at least one of the groups Z<1>, Z<2>, Z<3> is selected from -O-, -S-, -NH-, -N(-CH3)-, whereas the other groups Z<1>, Z<2>, Z<3> have the meaning of a -CH2- group, and in which Ar is an aromatic group. |