http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101676291-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48777bc90740675b5688a18fe3904cbd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05d8eb41e60efc608b75e37a0649d16c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7341f03f406b1bb3cf8b8b8ca97aff91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dc365d904f17702c76568fe771ebf7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b527cd28e862d8320e920eab649deb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37fdb83182c7d17c129236e0c4f57498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_479ac613b56b8e46cb3df5fc3827ccc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c68c57849386f42a7269397c559b0fb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6cf0f37d4f41a2fd8b4d7065bf5908e |
| publicationDate | 2012-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101676291-B |
| titleOfInvention | A kind of rapamycin carbonate analogue, its pharmaceutical composition and its preparation method and application |
| abstract | The invention belongs to the field of medicinal chemistry, and discloses a rapamycin carbonate analog shown in structural formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, a preparation method and application thereof. Compared with rapamycin, the rapamycin carbonate analog of the present invention enhances its water solubility by introducing water-soluble and polar groups such as hydroxyl groups, and its pharmacological and pharmacokinetic properties are improved. Biological tests on different tumor strains show that its antitumor activity is superior to that of rapamycin; compared with rapamycin and the marketed rapamycin analogue CCI-779, this type of compound has better pharmacokinetics The drug is more easily absorbed and distributed in tumor tissue; systematic immunosuppressive biological activity experiments show that this type of compound has higher immunosuppressive activity than rapamycin. The preparation method of the rapamycin carbonate analogue provided by the invention is simple, strong in operability, high in yield, and has good prospects for drug development. |
| priorityDate | 2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.