| abstract |
The invention relates to the technical field of medicine, in particular to a compound (3R)- des-O-methyllasiodiplodin obtained by extracting and separating from Cerbera in Chinese Mangrove, its derivatives and preparation method and use. The (3R)- des-O-methyllasiodiplodin and its derivatives has the following formula, if R1 and R2 are all hydrogen, the formula represents (3R)- des-O-methyllasiodiplodin. It is shown by the external detection that the compound and its derivatives have obvious steapsase inhibition activity, thus the compound and its derivatives can be used for preparing a medicament for preventing or treating the metabolic imbalance diseases such as obesity, diabetes, hyperlipidemia, fatty liver and the like. The invention also provides a lead compound for developing a new medicament for preventing or treating the metabolic imbalance diseases, thus the invention has important meaning for developing and using Chinese marine biological resources. |