abstract |
The present invention relates to modulators of ATP-Binding Cassette (''ABC'') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (''CFTR''), compositions thereof, andmethods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. Especially the invention relates to methods of modulating ABC transporters activity, comprising the step of making the ABC transporters contact with the formula (I) compound or its pharmaceutical acceptable salt, wherein each group in the formula (I) is defined asthe description. |