| abstract |
The invention discloses a preparation method which is characterized by using 7-methoxy-1-methyl-2-tetralone as an initial raw material to synthesize 5,6,7,8,9,10,11,12-octahydro-3-methoxy-5-methyl-5, 11-methylene benzocyclodecene-13-ketoxime. In the method, 1,5-dibromopentane is taken as an alkylating agent in alkaline environment in the presence of methylbenzene and other solution as well as phase transfer catalysts to carry out alkylation reaction, forms ring in the presence of sodium hydride and then reacts with hydroxylamine hydrochloride. The preparation method of the invention features mild reaction conditions, avoids the defects of low temperature required originally, requirement of high vacuum distillation, use of diethyl ether for extraction, complex operation and the like, and has the advantages of simple operation, high safety, good product quality and low cost, etc. |