| abstract |
The present invention is based on the anti-tumor activity of the tissue-accumulating chitosan gel of finding first, the antineoplastic pharmaceutical compositions that contains tissue-accumulating chitosan gel is provided.Tissue-accumulating chitosan gel of the present invention, preferably to have introduced the chitosan derivative of sugar chain, further contain and introduce the chitosan gel that photoreactive group makes it photocrosslinking in the sugar chain chitosan derivative, perhaps preferably comprised the chitosan gel of the polyion complex that contains sugar chain chitosan derivative and other material (for example acidic polysaccharose class) formation to this.Antineoplastic pharmaceutical compositions of the present invention only need be configured near the tumor does not need to contact tumor tissues, can suppress tumor growth. |