| abstract |
The invention relates to a preparation method of palonosetron and palonosetron hydrochloride and an injection, which belongs to the pharmaceutical chemical field. The invention provides the preparation method of the palonosetron, and the preparation method comprises the steps of reacting (1-aza-3(S)-bicyclo [2,2,2] octane base)-(1,2,3,4-tetralin-1S-methyl) amine with Bis(trichloromethyl)carbonate, and adding boron trifluoride to perform the reflux reaction to obtain the palonosetron. The preparation method has the advantages of simple process as well as high yield, good purity and low cost of the obtained products. |