http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101633624-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_378c4f2cab183e7e52f2792614ca03ca |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-157 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2009-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6632ff8d26d297452d7dfe08a29ac36d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a36422f30e657c368800ae82816685fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbda9f80c30d38d505b977d32c9d087f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfa6e299316ce04a38141b7982009d31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae5753eed975bd405ac5202696d33cc |
| publicationDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101633624-B |
| titleOfInvention | Preparation method of improved di-lysine-aspirin |
| abstract | The invention discloses a preparation method of improved di-lysine-aspirin, comprising the following steps: adding a DL-lysine aqueous solution with the mass percentage concentration being 25-30 percent to an alcobolic solution of aspirin at the temperature of 15-25 DEG C; enabling the mass ratio of DL-lysine to aspirin to be 1:(1.3-1):1.5; mixing and crystallizing for 5-15 minutes; then adding precipitation alcohol with the mass being 3-4 times of aspirin; reducing the temperature within 10 DEG C, and mixing and culturing crystal for 0.5-1.5 hours; filtering and then obtaining crystal; and washing the crystal by an amount of absolute ethyl alcohol for 1-2 times. The invention enables the acid value of a product to be reduced below 6.0 by changing the mixture ratio of reactants, enables the crystal fluidity of the product to be enhanced by changing the flow acceleration of materials and enables the appearance and free oxybenzoic acid of the product to be improved by reducing the temperature of the whole system, thereby reducing the acrimony and the sensitization of medicines and improving the quality of aspirin. |
| priorityDate | 2009-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.