http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101619070-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2009-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_253e90f8e70fd7f850e69d2a7a774652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f30c388f455a17472398c165895825eb |
| publicationDate | 2011-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101619070-B |
| titleOfInvention | Preparation method of tenoxicam |
| abstract | The invention provides a preparation method of tenoxicam shown in a chemical formula (I), which is characterized in that: evenly mixing Methyl 2-Methyl-4-Hydroxy-2H-Thieno[2,3-e]-1,2-Thiazine-3-Carboxylate-1,1-Dioxide shown in a chemical formula (II) and 2-aminopyridine in alkylbenzene; then adding alkali carbonate dried and activated at the temperature of 150 DEG C to the mixture and reacting for 10-20 hours at reflux temperature; separating crystals out after reaction products are cooled to 0-15 DEG C; then filtering; drying the filter cakes to obtain crude products; and obtaining the tenoxicam after the crude products are purified. The molar ratio of Methyl 2-Methyl-4-Hydroxy-2H-Thieno[2,3-e]-1,2-Thiazine-3-Carboxylate-1,1-Dioxide to 2-aminopyridine to alkylbenzene is 1 to 1-1.4 to 1-3. The preparation method has the advantages of reduced reaction temperature, shortened reaction time, complete reaction and reduced secondary reaction. The yield is higher than or equal to 85 percent,the raw materials and the reaction products can not be carbonized and decomposed, and a product is easy to purify. The invention is a tenoxicam synthesis process capable of realizing industrialized production. |
| priorityDate | 2009-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID408283367 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID147380896 |
Total number of triples: 14.