http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101616695-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate | 2007-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101616695-B |
| titleOfInvention | The alkalescence 2-nitroimidazole of histanoxia is detected for Noninvasive |
| abstract | The present invention mixes weakly alkaline substituent group (pKa is about more than 8 or 8) in halo 2-nitroimidazole, such as pyrrolidine, piperidines, piperazine and azepan part, it is the important improvement of the prior art detecting the cell hypoxia in normal structure and malignant tissue relative to Noninvasive.The invention is characterized in that [18F] positron emission fault shows the purposes of physiognomy, [19F] Magnetic Resonance Spectrum and [19F] nuclear magnetic resonance.6 aspects are had relative to the improvement of prior art compound.1) salt of alkalescence reagent is high water soluble, and it is conducive to administration.2) unreacted reagent is removed fast by systemic circulation, reduces background noise thus.3) there is the substituent reagent of alkalescence and to be concentrated on blood plasma level about 3 times in the tissue, increase bond strength and enhancing signal detection thus.4) alkali of puting together of alkalescence reagent has middle octanol-water partition coefficient, this be conducive to they penetrate comprise brain institute in a organized way.5) the cell adduct containing the substituent reagent of alkalescence is more stable than the reagent of prior art.6) there is the substituent reagent of alkalescence effective to the instantaneous anoxia detected in solid tissue. |
| priorityDate | 2006-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.