http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101575354-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7610cef0de1410bf21e1e54706e208a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2abfd229c12bc40b32600039bed22ee |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 |
| filingDate | 2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f21f2012368f553159ecc33ea087531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c5a743e0d813c894a7c2735d474c1b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d715c7ded51781bdd77bd838ebc9fdc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7799d2ee1a24a0661392c1a6bada9e49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb5aada9122ecd12491d5419277e88e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee531839f4094b5a106af3b3805d13af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74f271f9a66bb50774be9d74133d75bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f32eeb3fca040810f87a2acf8b3a10f |
| publicationDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101575354-B |
| titleOfInvention | Method for synthesizing Arbekacin and intermediate dibekacin thereof |
| abstract | The invention relates to an organic synthesis method, in particular to a method for synthesizing an Arbekacin and an intermediate dibekacin thereof. The method comprises the following steps of: takinga kanamycin B as initial raw material, carrying out the following processes of aldol condensation, sulfonylation, sodium iodide replacement and elimination to form double bond, de-protection under ac idic condition, amino-electron reduction and final hydrogenation, thus obtaining the dibekacin; taking 3',4'-dideoxy -3',4'-didehydro-kanamycin B as raw material, using a di-tert-butyl dicarbonate to selectively protect the amidogen of 3, 2', 6', 3'' sites; subsequently using the synthesized active ester to protect the 1-site amidogen; subsequently using tri-fluoroacetic acid to remove BOC; and carrying out hydrazinolysis and catalysis and hydrogenation of platinum oxide, thus obtaining the Arbekacin. The synthesis method has the advantages of simple operation, high outcome yield, reducing thecost of raw material, optimizing the reaction route, lowering the requirements to the reaction conditions and being beneficial to industrial production. |
| priorityDate | 2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.