http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101565390-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5cedb6fef482def25e4990072e8c8f7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 |
| filingDate | 2009-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ee5bbb98f9061bee7001d11aad4dbdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24f32c205a09c939761b5f30fe26be34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e2e1c6ef333e38ef785a6a3fd6ace48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98d7988b9650a3c473cd285b608c23df |
| publicationDate | 2009-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101565390-A |
| titleOfInvention | Method for preparing Alpha-methyl-Alpha, Alpha-disubstituted-Alpha-aminophenol and derivatives thereof |
| abstract | The invention discloses a method for preparing an Alpha-methyl-Alpha, Alpha-disubstituted-Alpha-aminophenol and derivatives thereof, comprising the following steps of: a) synthesizing S1/R1: leading proline to react with o-chlorobenzyl chloride; b) synthesizing S2/R2: leading methylene dichloride solution of S1/R1 to react with phosphorus trichloride and 2-aminobenzophenone; c) synthesizing S3/R3: leading S2/R2 and alanine to react with nickelous nitrate hexahydrate; d) synthesizing S4/R4: leading the redistilled tetrahydrofuran to react with sodium iodide, sodium hydride and R<1>X/R<2>X; e) synthesizing S5/R5: leading the methanol solution of S4/R4 to react with hydrochloric acid and concentrated ammonia liquor; and f) synthesizing S6/R6: leading S5/R5 to react with anhydrous sodium carbonate and Fmoc-Osu. The invention uses easily obtained raw materials with low price to obtain the Alpha-methyl-Alpha, Alpha-disubstituted-Alpha-aminophenol and derivatives thereof with extremely high optical activity by a normal six-step organic chemistry method. The method has moderate reaction condition and is easy for operation and amplification. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016503404-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101759601-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019059777-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10669230-B2 |
| priorityDate | 2009-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.