| abstract |
Disclosed is a compound represented by the general formula (Ia) or a salt thereof, which is a novel compound having a structure similar to that of curcumin and having an inhibitory activity on A beta aggregation, an activity of degrading an A beta aggregate, an inhibitory activity on beta-secretase and a neuronal cell protection activity. (Ia) wherein R<sp>1</sp> represents a 4-hydroxy-3-methoxyphenyl group or the like; and Ra<sp>2</sp> represents a 1H-indol-6-yl group or the like. |