http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101544630-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92b51345d31176aee5a78dbab3b5fae5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 2009-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_779ebd89d948c1c4a4ef225b9c97a7e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_388e47095b78907f761bd0248304fd5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f80025f46593b801905bfa2cf0ee214d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfba2b42de43e9c4b1d7a85fd68aac1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8d5660a06d783ac6da99ad75541986d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de582e5e6752398e5688ce60aca9fd68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66c08ebfad54cb62898a46caf641406c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c10aff5e7e4f3d873185e97590dde2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6da5579ddb69f97a971088d5bdc34ee2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cf29cc577242fb707dc8a54f8c9ba5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd8269caa91b81a6c6913ed0bcce53de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5551188c00c89867dae31c3f1adb1200 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e45469f4730de4cbe7778efe1625d76b |
| publicationDate | 2009-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101544630-A |
| titleOfInvention | Hydroxylated indinavir, preparation method of hydroxylated indinavir, and application of hydroxylated indinavir in preparation of antimalarials |
| abstract | The present invention provides hydroxylated indinavir represented by general formula (12). The present invention further provides a preparation method of hydroxylated indinavir, which employs cheap and widely available indene as the raw material, and comprises the following steps: dihydroxylate and protect the indene, oxidize the benzyl to introduce carbonyl, and then transform the carbonyl into amido, to obtain the required reaction intermediate; prepare the other molecular block from indinavir, carry out hydrolytic reaction, and protect the hydroxyl; then, carry out acidamide condensation with the reaction intermediate, remove the protection, to obtain the target product. The present invention further provides an application of hydroxylated indinavir in preparation of antimalarials, especially combination with chloroquini phosphas to treat malaria. The hydroxylated indinavir provided in the present invention has favorable in-vivo and in-vitro activity in inhibition of malarial parasite; when used in combination with chloroquini phosphas, it can works with chloroquini phosphas to inhibit malarial parasite that is resistant or sensitive to chloroquini phosphas in vitro and in vivo. The hydroxylated indinavir can be used to develop antimalarials and compound antimalarials, sets a basis for reapplying the economical and practical chloroquini phosphas in treatment of malaria, and has excellent application prospects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I402267-B |
| priorityDate | 2009-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.