| abstract |
The invention relates to a compound represented by the formula (1) or a salt thereof ( ---- represents a single bond, or a double bond; R<1> represents hydrogen atom, or an alkyl group; R<2> and R<3> represent hydrogen atom, or an alkyl group; R<4> and R<5> represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R<6> represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R<7> represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W ---- represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E 2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders. |