| abstract |
The invention relates to a niacin simvastatin slow-release preparation and a preparation method thereof. The slow-release preparation adopts the form of tablets, wherein a slow-release part of the preparation comprises simvastatin and pharmaceutical excipients, and a quick-release part of the preparation is taken as a coating to wrap a niacin slow-release part. Through a slow release technique, niacin is slowly released so as to reduce the toxic-side effects of the niacin. Meanwhile, after a coating technique is adopted, quick-release coating is performed, the quick-release part is good in 60-minute dissolution; and a slow-release layer forms gel which is released layer by layer and is insensitive to moisture, temperature and the like, so the quick-release coating has no obvious influence on the slow release of the niacin, and the synergy of the niacin and the simvastatin can reach optimum. |