http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101508684-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ca0d2e9af9d2ba81c0d9252732282aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 2009-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ac2ed57e6b6948d92c89089da1da15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29d59170b68124adefeebbf9661c3407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ce4771e9e5b56727433381c62e11bd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c03b6880b335e869e585e85c8043264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17651b8b9f3e18e143d4f107e87caede http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acea93810009495eb3bdf0227b071e23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edc0156a4af5f94c33f28f90762a7503 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cceef6316cb5cde282718d8b3af961e0 |
| publicationDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101508684-B |
| titleOfInvention | Synthesis of cinepazide maleate |
| abstract | A synthetic method of cinepazide maleate belongs to the pharmaceutical technical field. The synthetic method is characterized in that trans-3,4,5-trimethoxycinnamic acid is taken as a raw material, and a carboxy activator is employed to synthesize by a 'one pot' method to obtain cinepazide free alkali in the presence of organic base. The used activator is any one of alkyl chloroformate, methylsulfonyl chloride, benzene sulfonyl chloride, p-methylsufonyl chloride, diphenylphosphinyl chloride, 2,4,6-trimethylbenzenesulfonyl chloride, N,N-dicyclohexylcarbodiimide(DCC) and carbonyldiimidazole (CDI); ethyl chlorocarbonate is preferred, the reaction temperature is minus 10 DEG C and a solvent is dichloromethane. The cinepazide maleate is obtained after salifying the free alkali. The synthetic method has the effects and benefits of simplifying production conditions and procedure, avoiding application of a reactive intermediate trans-3,4,5-trimethoxycinnamoyl chloride, reducing environmental hazards and reducing equipment requirements; and providing a new synthetic route which is simple and easily controlled, has mild reaction conditions, is environment-friendly and applicable to large-scale industrial production. |
| priorityDate | 2009-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.