http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101497608-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f99ba87f39bb40c7fc87ba23db48307 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebe1cea03bbf8184539487c49d0a8c9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bad900771b7368a8fc01b91c3954ab8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf99a349fe69f9aa5750dbda7fa93cb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd023bd94bfbabfb8fa5c9e788a75aa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd8b522bf1a6b2da81d94953854ee6cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f039d68a79c31829bfb39405a1275435 |
| publicationDate | 2009-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101497608-A |
| titleOfInvention | HIV protease inhibitor derivative, preparation thereof and use in antineoplastic medicament preparation |
| abstract | The invention discloses HIV protease inhibitor derivatives, a preparation method thereof and application thereof in preparing anticancer drugs. The HIV protease inhibitor derivatives have a structure as shown by a genera formula X, the preparation for the HIV protease inhibitor derivatives adopts cheap and easily obtained indene as an initial raw material, the indene is dihydroxylated and protected, and then a carbonyl group is introduced through benzylic oxidation and then is converted into an amino group to obtain a needed reaction intermediate CH05-05. Another molecular building block is prepared from indinavir sulfate (CH05-05), the indinavir sulfate is subjected to hydrolysis reaction firstly, hydroxide radical is protected and then performs the condensation of acid amide with the CH05-05, and the obtained product is deprotected to obtain a target product. The HIV protease inhibitor derivatives can inhibit the activity of tumor cells and inhibit the growth of various tumor cell strains at the micromolar level, can be used for developing broad-spectrum anti-tumor drugs, and have broad application prospect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108324716-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774060-B2 |
| priorityDate | 2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.