| abstract |
The present invention concerns the compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y represents -C3-9alkyl-, -C1-5alkyl-NR<6>-C1-5alkyl- or -C1-5alkyl-NR<7>-CO-C1-5alkyl-; X<1> represents -O-; X<2> represents NR<5>-C1-2alkyl-; R<1> represents hydrogen, halo or Het<3>-O-; R<2> represents hydrogen; R<3> represents hydroxy, C1-4alkyloxy- or C1-4alkyloxy subst ituted with one or two substituents each independently selected from Het<4>, hydroxy, C1-4alkyloxy-, C1-4alkyloxy-C1-4alkyloxy and NR<9>R<10>; R<5> represents hydrogen or C1-4alkyl; R<6> represents hydrogen or C1-4alkyl; R<7> represents hydrogen; R<9> and R<10> each independently represent hydrogen; C1-4alkyl-S(=O)2-C1-4alkyl-C(=O)-; C1-4alkyl or C1-4alkyl substituted with hydroxy; Het<3> represents pyridinyl optionally substituted with C1-4alkyl; Het<4> represents morpholinyl, piperidinyl or piperazinyl wherein said Het<4> is optionally substituted with hydroxy-C1-4alkyl or C1-4alkyl-S(=O)2-C1-4alkyl-. |