| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d36a3825ab3db9da4c175046227e096 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5038
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2007-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3511a6a55212af9b15ea822625097ad1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3271fe5cb86274830aa9ecb70081c505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04fde81b3b436154ff3ed230a9092dce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78ff3741e2db1c6578b643ef20a974a4 |
| publicationDate |
2009-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-101467046-A |
| titleOfInvention |
CRAC modulators and use of same for drug discovery |
| abstract |
The invention relates to use of a calcium release activated Ca<+2> (CRAC) channel (CRACM) such as CRACM1 and CRACM2 to identify bioactive agents which can modulate store operated calcium entry and CRAC channel activity. The invention further relates to the use of recombinant nucleic acids that encode CRACM. One aspect of the invention includes methods of determining binding of candidate bioactive agents to a CRACM polypeptide and for determining modulation of CRACM polypeptide activity as it affects CRAC channel permeability. The invention further relates to methods and compositions modulating the cellular expression of the nucleic acids that encode CRACM. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104298891-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104298891-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106795512-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106795512-B |
| priorityDate |
2006-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |