| abstract |
Fused-ring, heterocyclic-substituted tricyclics of the formula formula (I) or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein (II) represents an optional double bond, and wherein An, En, Mn, Gn, Jn, R<3>, n7, R<8>, R<9>, R<10>, R<11>, R<32>, R<33>, X, Y, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed. |