http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101456860-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02f24694b4445e31254823f04656311e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 |
| filingDate | 2007-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21e2e6120c2ed97ca12dda7f43f13f93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8497717b6cc3fcd568121980fe7bb53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf53fe23724033645350a725220e9f2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9c511e6b06f225f718653b0ff3bec2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dc02dc86dded28bf66ca042049ea9a3 |
| publicationDate | 2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101456860-A |
| titleOfInvention | Process for preparing 4-[9-(6-aminopurine)]-2(S)-hydroxybutyrate methyl ester |
| abstract | The invention discloses a novel method for preparing and purifying 4-[9-(6-amino purine group)]-2 (S)-hydroxyl methyl butyrate. The method comprises: based on cheap and easily obtained L-malic acid, through functional group protection of one carboxyl and two carboxyls at the same time, an intermediate compound I is obtained; the intermediate compound I is selectively reduced into an intermediate ethanol II; the hydroxyl in the intermediate ethanol II is converted into an easily removed group, so as to obtain an intermediate compound III; the intermediate compound III is subjected to nucleophilic substitution reaction to obtain an intermediate compound IV; and the intermediate compound IV is subjected to protective group removal and methyl esterification simultaneously under the action of acid or alkali in the methanol to obtain a crude product of the 4-[9-(6- amino purine group)]-2 (S)-hydroxyl methyl butyrate, and a pure product is obtained after the crude product is recrystallized and purified. Compared with the prior preparation method, the method has the characteristics of low cost, mild conditions, difficult racemization of a chiral center during reaction, high production efficiency and the like, improves the quality and yield of products greatly, lowers the cost greatly, and is suitable for large-scale preparation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021047464-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107550913-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018001287-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107550913-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112472703-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112472703-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11045475-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103724317-A |
| priorityDate | 2007-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 232.