http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101445476-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-27 |
| filingDate | 2008-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30653bc3cf498220db7d64455acfc45e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6666896808cd604ea754bc751094a22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59321d7561fe64d2765b33c8cd5af272 |
| publicationDate | 2011-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101445476-B |
| titleOfInvention | Chemosynthesis method for Alpha-ethyl-2-oxo-1-methyl pyrrolidineacetate |
| abstract | The invention discloses a chemosynthesis method for Alpha-ethyl-2-oxo-1-pyrrolidine methyl acetate indicated in formula (I). The chemosynthesis method comprises the following steps: (1) under the protection of a noble gas, in an organic solvent, Alpha-ketopyrrolidine indicated in formula (II) is under the action of sodium tert-butoxide, wherein, the reaction temperature ranges from 0 DEG C to 60 DEG C and the reaction time ranges from 1 h to 5 h; and (2) 2-methyl butyrate bromide indicated in formula (III) is added in the reaction system of the step (1) so as to continue reacting for 1-20h ata temperature of 0-150 DEG C, and the Alpha-ethyl-2-oxo-1-pyrrolidine methyl acetate is obtained by post-processing reaction solution after the reaction. The invention adopts the sodium tert-butoxidefor generating sodium salt first, and then nucleophilic substitution reaction is carried out. Compared with the prior art which uses sodium hydride and phase transfer catalyst, the invention does notneed the phase transfer catalyst to participate in the reaction, has the advantages of simple and convenient operation, easy post-processing, low three-waste (waste gas, waste water and industrial residue) generation, low energy consumption, high product grade, and the like, and is a synthesis route with wide industrialization prospect. |
| priorityDate | 2008-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 17.