| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_081f82143e5b60ed3b786ed8f00b5650 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L29-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L29-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L29-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L29-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16 |
| filingDate |
2007-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33cfcd0d1e801036da4b0179335a51ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10b5a9cc533d3869a3f3f23de496171f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52d48f84a2b1aac9cae975f5a7d0c97b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b330c48a9e242b030cb975d335cc13d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f92e43a4bd54f8fab26c502300204cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a358990120410e6387d2fab6a0282144 |
| publicationDate |
2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-101400384-A |
| titleOfInvention |
Medical device with PH dependent drug release |
| abstract |
The invention provides intravascular devices coated with a first domain comprising an alkali formulation of polyethylenimine diazeniumdiolate . The alkali ensures stabilisation of the polyethylenimine diazeniumdiolate during processing of the medical device, whilst allowing controlled release of nitric oxide upon use. The invention also provides medical devices coated with a first domain of polyethylenimine diazeniumdiolate, and an outer-layer which prevents or hinders the release of polyethylenimine diazeniumdiolate upon use in the body, particularly from the alkali first domain. In a preferred embodiment a balloon is coated with linear poly (ethylenimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU) and provided with a top coat of poly acrylic acid and PU. |
| priorityDate |
2006-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |