| abstract |
The invention discloses a dual microsphere preparation of a hydrophilic drug, which consists of the hydrophilic drug, chitosan, sodium tripolyphosphate and a polylactic acid-glycolic acid copolymer. The invention also discloses a method for preparing the dual microsphere preparation: firstly, chitosan nanoparticles of the hydrophilic drug are prepared; secondly, the nanoparticles are dispersed in an acetonitrile or dichloromethane solution of PLGA and are evenly mixed to be used as suspension aqueous phase; finally, span80 is dissolved in edible oil to be used as oil phase; the oil phase is slowly dripped to the suspension aqueous phase while being stirred; acetonitrile or dichloromethane is removed; and the mixture is subjected to centrifugal collection and vacuum drying to prepare the dual microsphere preparation. The dual microsphere preparation of the hydrophilic drug has small burst effect, keeps the high encapsulation efficiency of the chitosan nanoparticles to the hydrophilic drug, is slowly released in vitro and is novel promising slow-release dosage of the hydrophilic drug. |