| abstract |
The invention relates to a matrix metallo-proteinase inhibitor, a pharmaceutical composition containing the matrix metallo-proteinase inhibitor, and a preparation method thereof and the application thereof. The matrix metallo-proteinase inhibitor has the structure of formula (I), wherein, the definitions of W, X1, X2, R1 and R2 are the same as the instruction book. The matrix metallo-proteinase inhibitor and the pharmaceutical composition containing the matrix metallo-proteinase inhibitor can be used for preventing and treating the diseases adjusted by matrix metalloproteinase, in particular for preventing and treating keratohelcosis, emphysema and skin ulcer caused by chemical injuries or emphysema caused by smoking or drowning. |