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filingDate 2008-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ea0fb4872ba5785bfa5385043764cb
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publicationDate 2008-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-101333246-A
titleOfInvention Neutral B cell antigen epitope polypeptide of encephalitis b virus E protein and uses thereof
abstract The invention discloses a polypeptides epitope in Japanese encephalitis virus E protein neutralizing B cell, also discloses the application of the polypeptides epitope in the prevention, treatment and diagnosis of Japanese encephalitis, belonging to the field of molecular immunology. The amino acid sequence of the polypeptides epitope disclosed in the invention is shown in SEQ ID NO: 1 or SEQ ID NO: 2. After being used as immunogen or vaccine immune animal organisms, the JEV E protein neutralizing B cell polypeptides epitope of the invention can produce neutralizing antibody against Japanese encephalitis virus, and can neutralize the Japanese encephalitis virus in vivo or in vitro so as to prevent the virus infecting animal organisms. The polypeptides epitope of the invention can immunise animals if being self-connected or inter-connected with carriers; the anti-peptide antibodies or the anti-Japanese encephalitis virus antibodies produced after the immunising of animals can neutralize the Japanese encephalitis virus in vitro and in vivo and generate immune protection.
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priorityDate 2008-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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