http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101307088-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-185 |
| filingDate | 2008-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f9601732a0dba1f26da65eee69bf620 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc87ac7ebf636d4a35866e36fa657618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fb3c5463f7cefcbeb20ff7d1fdd4db6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8843e04e7a7bf28c4fbfd6d75a57d2e1 |
| publicationDate | 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101307088-B |
| titleOfInvention | Method for preparing cholic acid conjugates |
| abstract | The invention provides a method for preparing a cholic acid coupler therapeutic medicine (I). The method adopts a taurine or glycinate compound as an initial material, and carries out a reaction to obtain the medicine (I) with the condensating agent of 2-chlorine-4,6-dimethoxy-1,3, 5-triazine or chloridized 4-(4,6- dimethoxy-1,3, 5-triazine-2-group)-4-methyl morpholine. The method has cheap and easily obtained raw material, gentle reaction conditions, solvent without water treatment, simple operation, high yield and friendly reaction environment. (In the formula, R1, R2, R3 represent H, alpha-OH, beta-OH, =O; R1, R2 and R3 can be the same or not the same; R represents CH2CH2SO3H, CH2COOH, CH2CH2SO3M, and CH2COOM; and M represents metallic ions). |
| priorityDate | 2008-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467416041 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID468104015 |
Total number of triples: 19.