| abstract |
The present invention relates to compounds of formula (1), or a pharmaceutically acceptable derivative thereof, wherein R<1> and R<3> independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R<2> represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R<4>, R<5>, R<7> and R<8> independently represent H, C1-6alkyl,C1-6alkyloxy, CN or halogen, or R<4> and R<5>, or R<7> and R<8>, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R<6> represents H, CN or halo, but when X represents N then R<6> represents H; may be useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome. |