| abstract |
The invention relates to 1-o-[3-aryl substituted-acrylyl]quinic acid compounds having the formula of (I), and an application thereof. The invention also relates to a preparation method of the quinic acid compounds, and intermediate compounds (II) of the quinic acid compound, i.e. 1-o-[3-aryl substituted-acrylyl]-3,4-o-isopropylidene quinic acid-1.5-lactone. The invention relates to pharmaceuticalapplication of the quinic acid compounds, and pharmaceutical compositions containing the same. The compounds having the formula (I) and the compounds having the formula of (II), and pharmaceutical salts thereof have the effects of inhibiting hepatitis B virus DNA replication and reducing hepatitis B virus surface antigen expression. Thus, the compounds having the formula of (I) and the compounds having the formula of (II) have pharmaceutical prospect application in the preparation of a drug for preventing and treating hepatitis B virus infectious disease. |