The invention relates to the preparation of a 1, 5-difuryl pentadiene ketones compound, which is the compound of the structural formula (I), wherein, R1 is fluoride atom, chlorine atom, bromine atom, methyl, ethyl, propyl and isopropyl; R2 is fluoride atom, chlorine atom, bromine atom, methyl, ethyl, propyl and isopropyl. The preparation can be applied to controlling plant diseases caused by bacteria or fungi.