| abstract |
The invention belongs to the anti-platelet aggregation drug technical field and provides Piperazine derivatives containing thieno pyridine with the structure as showed in general formula (I) and pharmaceutically acceptable salt thereof, wherein R1 and R2=hydrogen, methyl, ethide, carboxyl and hydroxyl; R3=hydrogen; C1-C4 is for alkyl; C5-C6 is for naphthenic base; CH2R5, COR6, SO2R7, R8, R9 and R10 replace phenyl; R11 replace heterocyclic radical, wherein the definition of R4-R11 is the same as described in the instructions. The invention also relates to a preparation method of the compound, and meanwhile discloses a drug combination that uses the compound or the pharmaceutically acceptable salt as active ingredients and an application thereof in respect to anti-platelet aggregation drugs. |