| abstract |
The invention provides a cycloheptane and pyridine compound as shown in formula I and pharmaceutically acceptable salt. The invention also relates to a preparation method for cycloheptane and pyridine compound as well as applications of the same in the preparation of the drugs for treating and preventing Alzheimer's disease, children's mental retardation syndrome, amnesia and other cardiovascular disease. The cycloheptane and pyridine compound can be used as alpha, beta, gamma-secretase agonist and/or inhibitors to prevent the production of beta-amyloid by agonizing or inhibiting enzyme activity so as to effectively treat and/or prevent Alzheimer's disease, children's mental retardation syndrome, amnesia and other cardiovascular disease. |