| abstract |
The invention relates to a cross-linked body of Tacrine and ferulic acid or a dynamic isomer, medicine salts, a pro-drug or a solvate thereof, wherein, the structural formula is shown in formula (I). The invention also relates to a method for making the same, a combination taking the formula (I) compound as active composition, and application of the compound and the combination thereof taken as the medicine for preventing and curing AChE-mediated diseases, in particular the application in preparation of the medicine for preventing Alzheimer diseases and dementia, in which other oxidative stresses take part. |