| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8925b769d645f9ff06af9f4b189f6a99 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate |
2006-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_265b2d1a9496fbdbd01a2961747718b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97286c055001fc80671270a3dad56133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00c9db961825371892b450b12be1e56d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ab312af833a5d8975fec160a30a71a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6761a76f9eae5df216004ce4e3a706bd |
| publicationDate |
2008-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-101277684-A |
| titleOfInvention |
Microparticles with modified release of at least one active principle and oral galenic form comprising same |
| abstract |
The invention concerns microparticulate systems with modified release of oral active principle(s). The invention aims at providing a novel multimicroparticulate galenic system operating in accordance with a dual time-dependent and pH-dependent release mechanism, which enables the following three parameters to be adjusted independently of one another: a) the latent period preceding the release of the active principle in the stomach; b) the pH triggering the release of the active principle in the intestine; c) the release speed of the active principle. This is achieved through the use of coated microparticles made from particles of active principle each coated with two coating films A and B. A comprises: film-forming (co)polymer (A1) insoluble in fluids of the gastrointestinal tract; ethylcellulose (co)polymer (A2) soluble in fluids of the gastrointestinal tract; plasticizing polyvinylpyrrolidone (A3); castor oil/optionally a surfactant and/or magnesium stearate lubricant (A4). B comprises a hydrophilic polymer (B1) bearing ionized groups with neutral pH (EUDRAGIT TM L100-55) and a hydrophobic compound (B2) (LUBRITAB TM ).The invention also concerns medicines based on said microparticules. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105611915-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113316441-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101966151-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105611915-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11311429-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111346093-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103608004-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102579405-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102552165-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113398069-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102316859-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111346093-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110575445-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110151731-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112220771-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110917195-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112137990-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102552165-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107811994-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103751789-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107811994-B |
| priorityDate |
2005-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |