| abstract |
The invention relates to a synthesis method for beta-amino propylene ketone compounds. The steps of the method are as follows: under the action of strong base, ketones or esters shown in the formula(II) and formic acid esters shown in the formula(III) undergo the addition reaction at a temperature of 10 DEG C below zero to 80 DEG C, obtaining intermediate salts shown in the formula(IV); the strong bases are chosen from sodium methoxide, sodium ethoxide, sodium tert-butoxide, caustic potash, sodium hydride and sodium hydroxide; the intermediate salts and amines shown in the formula(V) undergo the addition reaction at a temperature of 10 DEG C below zero to 80 DEG C, and after the reaction, the reaction solution undergoes the separation and purification, and the beta-amino propylene ketone compounds shown in the formula(I) are obtained. The method of the invention has the advantages of simple process, convenient post-treatment and high yield, and facilitates the industrialized production. |