| abstract |
The invention belongs to medicine technic field, and relates to a series of novel tetrahydrocurcumin derivates which is tetrahydrocurcumin mannich base derivates and the salts thereof. The constitutional general formula of such compounds is represented by I, wherein RI represents alkyl group, or substituted or unsubstituted aralkyl; R2 represents: (1) hydrogen, (2) aliphatic secondary amido methane, (3) substituted or unsubstituted annular aliphatic secondary amido methen. The salts include hydrochloride, hydrobromate, Methanesulfonates and other pharmaceutical salts. The compounds of the invention has substantial pharmacological activity of anticancer, oxidation resistance, free radical remove and repressing activation of small cells. |