| abstract |
Provided is 15-oxospiramilactone compounds represented by formula (I), which are used as antineoplastic compositions with active agent. The compounds and compositions thereof can overcome drug resistance of tumour cells due to loss of Bax, overcome resistance of tumour cells to chemotherapy medicine due to Bc1-2 high expression, and induce apoptosis of the Bc1-2 high expression cells; the compounds and compositions thereof also can induce apoptosis of mouse embryo epithelium free of Bax and Bak; restrain growth of HCT116 Bax-/- replant nude Mouse tumor, and display that 15-oxo spiraea lactone can be used as chemotherapy medicine and has no obvious damage on animal when killing tumour cells with resistance to a plurality of chemotherapy medicine. |