http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101238134-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5386 |
| filingDate | 2006-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca30c080bfcc8d93faa5667fc7281f6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_734ff38838258f0fad00937446393b2d |
| publicationDate | 2008-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101238134-A |
| titleOfInvention | Process for the preparation of sulfonic acid salts of oxabispidines |
| abstract | There is provided a process for the isolation of a sulfonic acid salt of formula I, or a solvate thereof, from a mixture comprising: (i) the corresponding free base; and (ii) a compound of formula III. or a salt and/or solvate thereof, which process comprises providing an aqueous dispersion of the compounds of formulae II and III and a source of R<3>SO3<-> anions and then, if necessary, adjusting the pH of the aqueous dispersion to any value from 3 to 8. There are further provided processes wherein the mixture of compounds of formulae II and III is provided by incomplete reaction, for example in the presence of base and an aqueous phase, between a compound of formula III and a compound of formula IV. In such processes, the RSO3<-> anions of the resulting salt of formula I may be derived from the compound of formula IV. Also, for all of these processes, D, R<1>, R<2> and R<3> have meanings given in the description. |
| priorityDate | 2005-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.