http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101234100-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 |
| filingDate | 2008-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e46dfd6207ff2e521359684ee6e468dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbd123a1f291f91c23dc8edfecfd9344 |
| publicationDate | 2011-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101234100-B |
| titleOfInvention | Application of naphthoquinone compounds |
| abstract | The invention provides application of naphthoquinones compound in preparing multidrug resistant tumor drug. The naphthoquinones compound is extracted or synthesized from gromwell plant by the prior art; the effective components of the naphthoquinones compound comprise iso-alkannin which is antimer of the gromwell and derivatives thereof. The naphthoquinones compound can take effect on the multidrug resistant tumor cells without being influenced by such tumor drug-resistant proteins as P-gp, MRP1 and BCRP, etc. and high expressions of anti-apoptotic proteins of Bc1-2 and Bc1-XL; the compound has lethal effects on the multidrug resistant tumor cells obviously superior to the presently common used and typical tumor resistant drugs; the lethal effects of the naphthoquinones compound on the multidrug resistant tumor cells is consistent with the parent drug-sensitive cells; the naphthoquinones compound is low toxic and has promising clinical application prospect therefore. |
| priorityDate | 2008-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.