| abstract |
The invention provides for compounds having formula (1) wherein, R<1> is O, (H,H), (H,OH), or NOR, with R being hydrogen, (C1-6) alkyl or (C1-6) acyl; R<2> is hydrogen, methyl, ethyl, or ethenyl; R<3> is hydrogen, methyl, ethyl, ethenyl, fluoro, or chloro; R<4> is methyl, or ethyl; R<5> is hydrogen, methyl, or ethyl; R<6> is hydrogen, methyl, ethyl, (C1-3) alkenyl, or (C1-3) alkynyl; R<7> is hydrogen or (C1-15) acyl; and at least one of R<5 >or R<6> is hydrogen; or a pharmaceutically acceptable salt thereof, for use as medicine for a treatment to increase androgen levels, for androgen supplementation, for testosterone replacement and for benign prostate hypertrophy and in a method of male contraception, preferably as sole means to achieve both progestagenic sterilitant effect and androgen supplementation. |