Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa48a431ce250933eb0fdd7a1caf3f30 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2037-0046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2037-0061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M37-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M37-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-17 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-08 |
filingDate |
2006-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9beaa349b46a09a4b70a88cd874f1d96 |
publicationDate |
2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-101189031-A |
titleOfInvention |
Method for terminal sterilization of transdermal delivery devices |
abstract |
A method and system for providing a terminally sterilized transdermal device adapted to delivery a parathyroid hormone-based agent. A microprojection member that includes a plurality of stratum corneum-piercing microprojections is coated with PTH-based agent formulation an exposed to sufficient radiation to sterilize the microprojection member while retaining sufficient activity of the PTH-based agent. Preferably, the microprojection member is sealed in packing with an inert atmosphere and reduced moisture. The sterilizing radiation can be gamma radiation or e-beam, preferably delivered in a dose in the range of approximately 5 - 50 kGy. Also preferably, the irradiation is performed at -78.5-25 DEG C. In preferred embodiments, the radiation is delivered at a rate greater than 3.0 kGy/hr. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112190725-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107454849-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107454849-B |
priorityDate |
2005-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |