| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| filingDate |
2006-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e2c943fd0fabc7c21dedc9e23250c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eac24d8c73d19f7c5f2a97406e38622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b133d409a0db36103f9826cc005ad9a2 |
| publicationDate |
2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-101111493-B |
| titleOfInvention |
3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors |
| abstract |
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula Vl or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (Vl) with metallo organic compounds (VII) give rise to the new compounds (VMI) which are direct precursors for the preparation of Aliskiren. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103121995-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103121995-A |
| priorityDate |
2005-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |