http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101111473-A

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
filingDate 2005-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6eee3ed4d6d0aced831570ed97e2e8b
publicationDate 2008-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-101111473-A
titleOfInvention Preparation of a quaternary ammonium hydroxide and use thereof for the preparation of q quaternary ammonium salt
abstract The invention relates to a process for the preparation of a quaternary ammonium hydroxide, in particular denatonium hydroxide, and the use thereof for the preparation of a quaternary ammo nium salt, in particular of denatonium benzoate or a denatonium fatty acid derivative. Due to its extremely bitter taste, this latter compound is applied in the art as an aversive agent, biocide, antifoulant and flavorant. It is usually prepared from a quaternary ammonium halide in an organic environment, which after isolation and purification is converted to a hygroscopic and unstable hydroxide intermediate, which in turn is immediately converted to the salt of interest in the solvent in which it is prepared. It is now found that these isolation steps can be avoided by performing the reaction at aqueous conditions. This is more straightforwardly and does not require costly precaut ions to avoid contact while handling. Moreover, the process of the invention allows to produce the quaternary ammonium salt from a lignocaine compound in a one-pot synthesis involving mostly water.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110354754-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112593078-A
priorityDate 2004-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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