| abstract |
An anthranilic acid derivative represented by the general formula (X) [wherein R<1> represents hydrogen or a carboxy-protecting group; R<2> represents optionally substituted phenyl, a heterocyclic group, etc.; R<3> represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X<1> represents carbonyl, etc.; X<2> represents optionally substituted alkylene, a bond, etc.; X<3> represents oxygen, a bond, etc.; and X<4> represents a group represented by the general formula -X<5>-X<6>- or -X<6>-X<5>- (wherein X<5> means oxygen, a bond, etc.; and X<6> means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has an MMP-13 production inhibitory activity and is hence useful as a therapeutic agent for articular rheumatisum, osteoarthritis, cancer, etc. |